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In statistics, a volcano plot is a type of scatter-plot that is used to quickly identify changes in large data sets composed of replicate data.[1] It plots significance versus fold-change on the y and x axes, respectively. These plots are increasingly common in omic experiments such as genomics, proteomics, and metabolomics where one often has a list of many thousands of replicate data points between two conditions and one wishes to quickly identify the most meaningful changes. A volcano plot combines a measure of statistical significance from a statistical test (e.g., a p value from an ANOVA model) with the magnitude of the change, enabling quick visual identification of those alttext='{displaystyle y=e^{-x^{2}}}'>
So the of that is
and the negative is
which is a parabola whose arms reach upwardson the left and right sides.The upper bound of the data is one parabolaand the lower bound is another parabola.
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References[edit]
- ^Cui, X.; Churchill, G. A. (2003). 'Statistical tests for differential expression in cDNA microarray experiments'. Genome Biology. 4 (4): 210. doi:10.1186/gb-2003-4-4-210. PMC154570. PMID12702200.
- ^Li, W. (2012). 'Volcano plots in analyzing differential expressions with mRNA microarrays'. Journal of Bioinformatics and Computational Biology. 10 (6): 1231003. arXiv:1103.3434. doi:10.1142/S0219720012310038. PMID23075208.
- ^Li, W.; Freudenberg, J.; Suh, Y. J.; Yang, Y. (2014). 'Using volcano plots and regularized-chi statistics in genetic association studies'. Computational Biology and Chemistry. 48: 77–83. arXiv:1308.6245. doi:10.1016/j.compbiolchem.2013.02.003. PMID23602812. S2CID12399345.
External links[edit]
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